Revealing the Lifestyle Factors Shaping Alzheimer's

Written by Chris Claussen, Co-Founder, Chief Innovation Officer


About the Author: Chris has over 20 years of experience in product and business development. For the past five years he has focused exclusively on innovative product development in the functional foods and functional mushrooms space. Chris brings experience exploring, experimenting, and conducting extensive research on the relationship between functional foods/ mushrooms and metabolic, brain, and mental health.​


As the relentless grip of Alzheimer's disease continues to impact an ever-growing segment of the baby boomer generation, a widespread misconception persists. Alzheimer's is often seen as an inexorable fate, a capricious affliction that strikes without warning. Observing individuals in their late 70s or early 80s who have evaded Alzheimer's can seem like a stroke of luck.

Within the realm of traditional medicine, it is customary for healthcare professionals to reassure patients grappling with memory lapses that these lapses are attributed to the normal process of age-related memory decline, reinforcing the belief that Alzheimer's is an unstoppable juggernaut, impervious to prevention or treatment. For many years, it was widely believed that Alzheimer's disease had a predominantly genetic underpinning, with specific genes like APOE4 playing a pivotal role in its development. 

However, the reality is far more nuanced.

Alzheimer's, it turns out, is profoundly influenced by lifestyle factors, a realm known as epigenetics. Much like conditions such as heart disease or type 2 diabetes, the daily choices and habits we adopt play a substantial role in determining our vulnerability to this condition. Epigenetics delves into the alterations in gene expression influenced by environmental factors rather than changes to the underlying DNA sequence itself. Importantly, it suggests that lifestyle choices, including diet, exercise, stress management, and sleep, can exert significant influence over these epigenetic processes.

Though Alzheimer's possesses a genetic component, the presence of certain genetic variants, such as APOE4, merely indicates a heightened susceptibility to the disease. Carrying these genes does not guarantee an individual will develop Alzheimer's. 

The impact of diet on our epigenetics cannot be overstated. The Standard American Diet (SAD), characterized by high consumption of processed foods, sugar, industrial seed oils, and low-nutrient foods, profoundly influences our epigenetic landscape. This dietary pattern has far-reaching implications for brain health and contributes to the development of chronic diseases, including Alzheimer's. The SAD is notorious for promoting chronic inflammation throughout the body, including the brain—an inflammation increasingly recognized as a pivotal driver of Alzheimer's. This inflammation triggers the release of detrimental molecules called cytokines, leading to brain cell death and the formation of amyloid plaques, a hallmark of Alzheimer's.

Moreover, excessive intake of processed foods and unhealthy fats leads to oxidative stress, an imbalance between harmful free radicals and antioxidants, particularly damaging to brain cells and implicated in Alzheimer's disease progression. The SAD also plays a significant role in blood sugar dysregulation and insulin resistance, both of which are risk factors for Alzheimer's, sharing common pathways with inflammation and insulin resistance.

Emerging research illuminates the intricate connection between gut health and brain health. The SAD's lack of fiber and overconsumption of processed foods negatively impact the gut microbiome, potentially influencing brain function through the gut-brain axis.

The revelation that Alzheimer's disease is, in part, a lifestyle disease offers a beacon of hope for prevention and intervention. While there may not be a one-size-fits-all approach, adopting certain lifestyle changes can significantly reduce the risk of Alzheimer's.

In summary, these key lifestyle strategies can promote brain health and reduce the risk of Alzheimer's:

  1. Nutrient-Rich Diet: Prioritize whole foods, including berries, cruciferous vegetables, pasture-raised proteins, and healthy fats, which are rich in brain-boosting nutrients like omega-3 fatty acids, antioxidants, and polyphenols.
  2. Regular Exercise: Engage in a balanced exercise routine, including aerobic, strength training, and flexibility exercises, to improve blood flow, reduce inflammation, and support brain cell growth.
  3. Stress Management: Employ stress-reduction practices such as mindfulness meditation, yoga, deep breathing, and spending time in nature to mitigate the detrimental effects of chronic stress.
  4. Deep Restorative Sleep: Prioritize 7-9 hours of quality sleep nightly to allow your brain to rest, repair, and consolidate memories.
  5. Social Engagement: Maintain social connections and active engagement in social activities to preserve cognitive function.
  6. Cognitive Stimulation: Challenge your brain with mentally stimulating activities like reading, puzzles, language learning, or pursuing new hobbies.
  7. Manage Chronic Conditions: Work with healthcare providers to effectively manage conditions like hypertension, diabetes, or high cholesterol, as controlling these can reduce Alzheimer's risk.
  8. Limit Toxins: Minimize exposure to environmental toxins, such as air pollution and pesticides, which some studies suggest may increase Alzheimer's risk.
  9. Regular Health Check-ups: Stay vigilant with healthcare check-ups to identify and manage Alzheimer's risk factors early, including a discussion of your family history and cognitive function concerns. 

As I witness my third direct family member enduring the tragic grasp of Alzheimer's, it reinforces the urgency of our mission at First Person. Our purpose is to seamlessly integrate brain health into everyday life. In doing so, we aim to wield the power of epigenetics to diminish the specter of cognitive decline.

By embracing a brain-boosting lifestyle, you can chart a proactive course toward safeguarding your cognitive well-being, offering hope and the possibility of lowering your vulnerability to Alzheimer's disease.

In Health,



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